Bingefors K, Isacson D, Von Knorring L, Smedby B, Ekselius L, Kupper L L
Br J Psychiatry. 1996 Mar;168(3):292-8. doi: 10.1192/bjp.168.3.292.
Despite the problems involved in treating depression and concomitant medical disease, there are virtually no longitudinal studies on drug utilisation among depressed patients.
Use of prescription drugs among all first-time users of antidepressants in a defined population five years before and six years after the index (first) treatment was compared to a referent group without antidepressant treatment. The generalised estimating equations (GEE) method was used for analysis.
The antidepressant-treated group used considerably more non-psychotropic drugs during the whole study period than the referent group. They also used more psychotropic drugs, a use which increased in connection with the initiation of antidepressant treatment, and stayed high for a further five years.
The high use of prescription drugs indicated widespread somatic and psychiatric health problems during the whole study period. Antidepressant-treated patients are at risk for drug interactions and adverse effects, and would benefit from a closer collaboration between psychiatry and medicine.
尽管治疗抑郁症及伴发的内科疾病存在诸多问题，但几乎没有关于抑郁症患者药物使用情况的纵向研究。
将某特定人群中所有首次使用抗抑郁药者在索引（首次）治疗前五年及治疗后六年的处方药使用情况，与未接受抗抑郁药治疗的参照组进行比较。采用广义估计方程（GEE）方法进行分析。
在整个研究期间，接受抗抑郁药治疗的组使用的非精神类药物比参照组多得多。他们使用的精神类药物也更多，这种使用情况在开始抗抑郁药治疗时增加，并在接下来的五年里一直居高不下。
处方药的高使用量表明在整个研究期间存在广泛的躯体和精神健康问题。接受抗抑郁药治疗的患者有药物相互作用和不良反应的风险，精神病学与医学之间更密切的合作将使他们受益。
