MacEwan T H, Morton M J
Br J Psychiatry. 1996 Mar;168(3):376-8. doi: 10.1192/bjp.168.3.376.
Schizophrenia can be diagnosed in adults and requires treatment with antipsychotic medication. Clozapine is used effectively in adults with treatment-resistant schizophrenia but little is published on the use of clozapine in children.
Supported by parental consent and a second opinion, standardised observations were used to chart the progress of treatment with clozapine in a child in-patient detained under mental health legislation with severe drug-resistant schizophrenia and tardive dyskinesia.
Sixteen months of clozapine treatment led to significant reduction of symptomatology with marked improvement in social functioning and diminished tardive dyskinesia.
This case illustrates the successful use of clozapine in treatment-resistant childhood schizophrenia.
精神分裂症可在成人中诊断出来，且需要使用抗精神病药物进行治疗。氯氮平在治疗难治性精神分裂症的成人患者中疗效显著，但关于氯氮平在儿童中的使用情况，相关文献报道较少。
在获得家长同意及二次评估支持的情况下，采用标准化观察方法，记录一名依据精神卫生法被拘留的患有严重耐药性精神分裂症和迟发性运动障碍的儿童住院患者使用氯氮平的治疗进展情况。
16个月的氯氮平治疗使症状显著减轻，社会功能明显改善，迟发性运动障碍症状减轻。
本病例表明氯氮平在治疗儿童难治性精神分裂症方面取得了成功。
