Bury T B, Louis R, Radermecker M F, Pirnay F
Department of Pneumology, CHU Sart Tilman, Liege, Belgium.
Int J Sports Med. 1996 Feb;17(2):156-60. doi: 10.1055/s-2007-972825.
This study was designed to compare the effects of three prolonged exercises varying in their intensity and duration, on blood mononuclear cell mobilization and cytokine secretion (IL1(1)-IL(2)). Seven healthy subjects underwent three effort trials (45 % VO(2)max during 4 h - 60% VO(2)max during 3 h - 75 % VO(2)max during 2 h) at one-month intervals. Blood samples were drawn before, different times during exercise and also after exercise. Prolonged exercises induced a transient increase in blood mononuclear cells which occurred across all intensity levels. We also observed a significant increase in plasma IL(1) level during exercise which correlates with the exercise intensity. The mean IL(1) level increased up to 2.5 times after the three proposed exercises (p <0.05). Plasma IL(2) level decreased at the end of prolonged exercises irrespective of the exercise intensity. No correlation was observed between blood mononuclear count and cytokine determination. Our data suggest that blood mononuclear cells mobilization is associated but not correlated with alterations of cytokine levels.
本研究旨在比较三种强度和持续时间不同的长时间运动对血液单核细胞动员和细胞因子分泌（IL-1 - IL-2）的影响。七名健康受试者每隔一个月进行三次运动试验（4小时运动强度为45%最大摄氧量 - 3小时运动强度为60%最大摄氧量 - 2小时运动强度为75%最大摄氧量）。在运动前、运动过程中的不同时间以及运动后采集血样。长时间运动导致血液单核细胞短暂增加，且在所有强度水平均出现这种情况。我们还观察到运动期间血浆IL-1水平显著升高，且与运动强度相关。在进行了三种预设运动后，IL-1平均水平升高至2.5倍（p <0.05）。无论运动强度如何，长时间运动结束时血浆IL-2水平均下降。血液单核细胞计数与细胞因子测定之间未观察到相关性。我们的数据表明，血液单核细胞动员与细胞因子水平的变化有关，但无相关性。
