Feldman P D, Parveen N, Sezen S
Department of Pharmacology and Experimental Therapeutics, Louisiana State University Medical Center, New Orleans, USA.
Brain Res. 1996 Feb 19;709(2):331-36. doi: 10.1016/0006-8993(95)01434-9.
Microinjections of Leu-enkephalin into the dorsal vagal complex induced hypotension and bradycardia. Both naloxone, given at a dose conferring selectivity for mu receptors, and the delta antagonist ICI 154,129 prevented the cardiovascular effects of Leu-enkephalin. Naloxone was also found to decrease the gain of the baroreflex. These results suggest that Leu-enkephalin is involved in cardiovascular regulation through activation of delta-, and possibly mu-, opioid receptors in the dorsal vagal complex.
向迷走神经背侧复合体微量注射亮氨酸脑啡肽可引起低血压和心动过缓。给予对μ受体具有选择性的剂量的纳洛酮以及δ拮抗剂ICI 154,129均可预防亮氨酸脑啡肽的心血管效应。还发现纳洛酮可降低压力感受性反射的增益。这些结果表明，亮氨酸脑啡肽通过激活迷走神经背侧复合体中的δ - 以及可能的μ - 阿片受体参与心血管调节。
