Makarov A Iu, Kiselev V N, Loboda E B, Paniushkin A I, Kozlov S V
Zh Vopr Neirokhir Im N N Burdenko. 1977 May-Jun(3):39-44.
In patients with brain tumours there was revealed an increase in the content of serotonin, 5-oxyindol acetic acid (5-OAA) and melatonin in the liquor, and of serotonin in the plasma rich with platelets. The content of serotonin or products of its metabolism in the liquor, as well as of serotonin in platelets depends on the involvement of truncus cerebri and hypothalamus in the pathologic process and on the gravity of the patient's condition. The serotonin content, in contrast to 5-OAA, s significantly higher in patients with tumours attended by epileptic attacks. The data obtained testify to a possible role of serotonin in the pathogenetic mechanisms of tumours development in the central nervous system.
在脑肿瘤患者中，发现脑脊液中血清素、5-羟吲哚乙酸（5-OAA）和褪黑素的含量增加，富含血小板的血浆中血清素含量也增加。脑脊液中血清素或其代谢产物的含量，以及血小板中血清素的含量，取决于脑干和下丘脑参与病理过程的程度以及患者病情的严重程度。与5-OAA相比，癫痫发作的肿瘤患者血清素含量显著更高。所获得的数据证明血清素在中枢神经系统肿瘤发生机制中可能发挥作用。
