Mundal H H, Rostrup M
Department of Cardiology, University of Oslo, Norway.
Am J Hypertens. 1996 Jan;9(1):12-7. doi: 10.1016/0895-7061(95)00263-4.
Healthy 19-year old males from the 95th percentile of mean arterial screening blood pressure were randomized to prolonged mental stress by receiving a letter informing of a high screening blood pressure (n = 13), or a neutral letter (n = 13). Blood platelet function in vivo was assessed by measurements of plasma concentrations of the platelet-specific protein beta-thromboglobulin, platelet counts, and mean platelet volumes before and during two laboratory stress tests (hand cold pressor test and arithmetic challenge). The cold pressor test caused a significant increase in beta-thromboglobulin concentrations in both groups, and significantly more in the uniformed group. Platelet count increased significantly in both groups during mental arithmetic with significantly higher counts in the uninformed group. Overall plasma beta-thromboglobulin responses were significantly larger in the uninformed group. This study demonstrates that laboratory stress is associated with blood platelet activation and that awareness of high blood pressure attenuates the platelet responses to such stress tests.
将平均动脉筛查血压处于第95百分位数的19岁健康男性随机分组，一组收到告知其筛查血压高的信件（n = 13），使其承受长时间精神压力，另一组收到中性信件（n = 13）。在两项实验室应激测试（手部冷加压试验和算术挑战）之前及期间，通过测量血小板特异性蛋白β-血小板球蛋白的血浆浓度、血小板计数和平均血小板体积，评估体内血小板功能。冷加压试验使两组的β-血小板球蛋白浓度均显著升高，且穿制服组升高得更显著。心算过程中两组的血小板计数均显著增加，未被告知组的计数显著更高。总体而言，未被告知组的血浆β-血小板球蛋白反应显著更大。本研究表明，实验室应激与血小板激活有关，且知晓高血压会减弱血小板对此类应激测试的反应。
