Gómez Gerique J A, Porres A, López Martinez D, Alvarez Sala L A, Blazquez E, Montoya M T, De Oya M
Departamento de Bioquímica Clínica, Fundación Jiménez Díaz, Madrid, Spain.
Acta Paediatr. 1996 Jan;85(1):38-42. doi: 10.1111/j.1651-2227.1996.tb13887.x.
Increased plasma lipoprotein(a)-Lp(a)-levels are linked to a high risk of cardiovascular disease unrelated to other lipoproteins. It seems that Lp(a) values in childhood remain unaltered up to adulthood. In a randomly chosen population of 1970 children, aged from 4 to 18 years and living in a Spanish community, the following serum parameters were studied: total cholesterol, total triglycerides, Lp(a), high-density lipoprotein cholesterol and low-density lipoprotein cholesterol. Mean Lp(a) serum values were 15.0 +/- 14.7 mg dl-1. No differences were seen between either sex in the first years of childhood. Of the studied children, 15.1% presented Lp(a) concentrations above 30 mg dl-1. A correlation between Lp(a) and total cholesterol concentrations, which disappeared when low-density lipoprotein cholesterol concentrations were corrected according to cholesterol present in Lp(a), was observed.
血浆脂蛋白(a)[Lp(a)]水平升高与心血管疾病高风险相关，且独立于其他脂蛋白。儿童期至成年期Lp(a)水平似乎保持不变。在西班牙某社区随机选取的1970名4至18岁儿童中，研究了以下血清参数：总胆固醇、总甘油三酯、Lp(a)、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇。Lp(a)血清均值为15.0±14.7mg/dl。儿童早期两性之间未见差异。在研究的儿童中，15.1%的Lp(a)浓度高于30mg/dl。观察到Lp(a)与总胆固醇浓度之间存在相关性，但在根据Lp(a)中的胆固醇校正低密度脂蛋白胆固醇浓度后，该相关性消失。
