Kordonouri O, Danne T, Hopfenmüller W, Enders I, Hövener G, Weber B
Children's Hospital of the Virchow-Klinikum, Humboldt University of Berlin, Germany.
Acta Paediatr. 1996 Jan;85(1):43-8. doi: 10.1111/j.1651-2227.1996.tb13888.x.
The objective of this study is to examine the influence of lipid profiles and blood pressure on the development of microvascular complications in adolescents with insulin-dependent diabetes mellitus (IDDM) in a matched pairs study. Patients with early background retinopathy (n = 21) or microalbuminuria (n = 15) and their respective statistical twins participated in the study. Serum total cholesterol, high-density lipoprotein (HDL) cholesterol, fasting triglycerides, glycosylated haemoglobin A1c (HbA1c), and systolic and diastolic blood pressure during 3 years prior to the development of early background retinopathy or incipient nephropathy were examined. The multivariate discriminant analysis demonstrated glycaemic control and HDL cholesterol to be the most important variables related to the development of retinal lesions (84% correctness), and diastolic blood pressure to be associated with microalbuminuria (57% correctness). In addition to poor glycaemic control, different factors seem to be important for the early retinal or renal lesions of juvenile IDDM.
本研究的目的是在一项配对研究中，探讨血脂谱和血压对胰岛素依赖型糖尿病（IDDM）青少年微血管并发症发生发展的影响。患有早期背景性视网膜病变（n = 21）或微量白蛋白尿（n = 15）的患者及其各自的统计学双胞胎参与了该研究。检测了在早期背景性视网膜病变或早期肾病发生前3年期间的血清总胆固醇、高密度脂蛋白（HDL）胆固醇、空腹甘油三酯、糖化血红蛋白A1c（HbA1c）以及收缩压和舒张压。多变量判别分析表明，血糖控制和HDL胆固醇是与视网膜病变发生相关的最重要变量（正确率84%），舒张压与微量白蛋白尿有关（正确率57%）。除血糖控制不佳外，不同因素似乎对青少年IDDM的早期视网膜或肾脏病变很重要。
