Frequency-following responses in primary auditory and reticular formation structures.

The responses of the cat brain to tonal stimuli were recorded from the inferior colliculus, medial geniculate, reticular formation and the far field. The response consisted of an onset component and a frequency-following response (FFR) component in the inferior colliculus (IC) and the far field. In contrast to previous work, the FFR was also observed in the reticular formation. The response in the reticular formation was abolished at lower doses of pentobarbital and at lower relative intensities of masking than that in the IC and far field. The amplitude of the FFR increased and the latency decreased with progressive ventral movement of the electrode through the IC. The onset component of the response in IC was more easily masked than the FFR component, while the FFR component was depressed to a somewhat greater extent by pentobarbital administration. These findings suggest that the different components of the response to tonal stimuli are generated by different mechanisms.