Giovagnoni A, Paci E, Valeri G, Ercolani P, Gesuita R, Carle F, Piga A
Department of Radiology, University of Ancona, NMR Center Angelini, Ospedale Torrette, Italy.
J Magn Reson Imaging. 1996 Jul-Aug;6(4):589-95. doi: 10.1002/jmri.1880060406.
Forty-one patients with 61 proved focal liver lesions underwent MRI of the liver at 1.0 T, with the aim of evaluating the usefulness of turbo spin-echo (TSE) sequences in characterizing focal liver lesions, by comparing them with conventional spin-echo (CSE) sequences. Two different TSE protocols were employed. with constant echo time and varying repetition time: TSE-S (3000 msec) and TSE-L (5100 msec). All images were evaluated quantitatively (signal-to-noise ration 'SNR') and qualitatively: because benign lesions were all liquid (12 cysts and 10 hemangiomas), they were well characterized morphologically on the basis of signal intensity. Mean SNR was significantly different between metastases and benign lesions (P < .0001) with all T2 sequences. Among the single T2 sequences tested, logistic regression analysis showed TSE-L to have the best predictive ability of the nature of focal lesions, with a G value of 42.02, compared to 29.87 of TSE-S and 25.55 of CSE second echo (SE II). The combination of TSE-L with TSE-S did not modify these results, whereas the combination of TSE-L with CSE only resulted in slight improvement (G = 46.95). Comparison of the receiver operating characteristic (ROC) curves showed only SE II (area under the ROC curve of .8312) to be significantly inferior to the best single sequence, or TSE-L (area under the ROC curve of .9176; P = .027). All sequences were equivalent in qualitative evaluation with good reproducibility, sensitivity ranging from .94 to 1.0 and specificity ranging from .86 to .93. This study confirms the value of TSE sequences in characterization of focal liver lesions. Time of acquisition is strongly reduced with these sequences, whereas results are fairly similar to those obtained with CSE. TSE sequences could therefore replace CSE for the study of focal liver lesions.
41例有61个已证实的局灶性肝病变的患者接受了1.0T肝脏MRI检查，目的是通过将涡轮自旋回波（TSE）序列与传统自旋回波（CSE）序列进行比较，评估TSE序列在局灶性肝病变特征性诊断中的作用。采用了两种不同的TSE方案，回波时间恒定，重复时间不同：TSE-S（3000毫秒）和TSE-L（5100毫秒）。所有图像均进行了定量（信噪比‘SNR’）和定性评估：由于良性病变均为液性（12个囊肿和10个血管瘤），根据信号强度在形态学上易于鉴别。所有T2序列中，转移瘤与良性病变之间的平均SNR有显著差异（P <.0001）。在测试的单个T2序列中，逻辑回归分析显示TSE-L对局灶性病变性质的预测能力最佳，G值为42.02，相比之下，TSE-S为29.87，CSE第二回波（SE II）为25.55。TSE-L与TSE-S联合使用并未改变这些结果，而TSE-L与CSE联合使用仅略有改善（G = 46.95）。接受者操作特征（ROC）曲线比较显示，只有SE II（ROC曲线下面积为.8312）明显不如最佳单序列，即TSE-L（ROC曲线下面积为.9176；P =.027）。所有序列在定性评估中相当，具有良好的可重复性，敏感性范围为.94至1.0，特异性范围为.86至.93。本研究证实了TSE序列在局灶性肝病变特征性诊断中的价值。这些序列显著缩短了采集时间，而结果与CSE序列相当。因此，TSE序列可替代CSE用于局灶性肝病变的研究。
