Sanderson S, Osborne C, Lulich J, Pierpont M E, Gross K, Ogburn P, Koehler L, Carvalho M
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA.
Am J Vet Res. 1996 Aug;57(8):1185-8.
To evaluate the reliability of urine carnitine concentrations measured in single postprandial samples, compared with carnitine concentrations measured in 24-hour urine samples.
19 healthy Beagles.
After emptying the urinary bladder by catheterization, dogs were fed a canned canine maintenance diet. Approximately 8 hours later, urine, plasma, and serum samples were obtained for determination of urinary carnitine fractional excretion and urine carnitine-to-creatinine concentration ratio. Results were compared with 24-hour urinary carnitine excretion rate.
Fractional excretion of carnitine and urine carnitine-to-creatinine ratios correlated poorly with 24-hour urinary carnitine excretion.
Determination of 24-hour urinary carnitine excretion is recommended to measure urine carnitine concentrations in dogs.
与24小时尿液样本中测得的肉碱浓度相比，评估单次餐后样本中测得的尿肉碱浓度的可靠性。
19只健康的比格犬。
通过导尿排空膀胱后，给犬喂食罐装维持性犬粮。约8小时后，采集尿液、血浆和血清样本，用于测定尿肉碱排泄分数和尿肉碱与肌酐浓度比。将结果与24小时尿肉碱排泄率进行比较。
肉碱排泄分数和尿肉碱与肌酐比与24小时尿肉碱排泄的相关性较差。
建议测定24小时尿肉碱排泄量以测量犬尿液中的肉碱浓度。
