嗅神经母细胞瘤：病例报告

Olfactory neuroblastoma: a case report.

作者信息

Griego J E, Mackay B, Ordóñez N G, Langford L, Batsakis J G

机构信息

Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.

出版信息

Ultrastruct Pathol. 1996 Jul-Aug;20(4):399-406. doi: 10.3109/01913129609016342.

DOI:10.3109/01913129609016342

PMID:8837348

Abstract

A neuroblastoma arising in the nasal cavity of a 66-year-old male invaded the frontal sinus and extended into the cranial cavity. Light microscopy revealed sheets of small ovoid cells and many small glands bordered by columnar cells which were strongly immunoreactive to epithelial markers. Focal reactivity for synaptophysin and chromogranin was seen within the sheets of small cells. Electron microscopy confirmed the presence of olfactory differentiation.

摘要

一名66岁男性鼻腔内发生的神经母细胞瘤侵犯了额窦并延伸至颅腔。光镜检查显示有小卵圆形细胞片和许多由柱状细胞围成的小腺体，这些柱状细胞对上皮标志物呈强免疫反应性。在小细胞片中可见突触素和嗜铬粒蛋白的局灶性反应。电镜检查证实存在嗅觉分化。