Sutherland W H, Pritchard J A, Smith C W
Ann Clin Res. 1977 Apr;9(2):45-51.
As the sensitivity of the new in vitro cancer detection techniques increases, a larger number of "false positive" results can be expected from control populations apparently free from malignant disease at the time of the test. An attempt is made to predict the number of unexplained positives, together with the expected age and sex distribution, using published cancer registration statistics. The predicted numbers are compared with the observed numbers of unexplained positives in two clinical trials of the MEM test.
随着新型体外癌症检测技术灵敏度的提高，预计在检测时看似无恶性疾病的对照人群中会出现更多“假阳性”结果。我们尝试利用已发表的癌症登记统计数据来预测不明原因阳性结果的数量，以及预期的年龄和性别分布。将预测数量与MEM检测的两项临床试验中观察到的不明原因阳性结果数量进行比较。
