Darney P D, Taylor R N, Klaisle C, Bottles K, Zaloudek C
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, USA.
Contraception. 1996 Feb;53(2):97-100. doi: 10.1016/0010-7824(95)00266-9.
The objective of this study was to determine the relevance of serum estradiol, progesterone and levonorgestrel concentrations to endometrial histology and uterine bleeding associated with long-term Norplant implants use. Eighteen five-year users of Norplant implants had endometrial biopsies and determinations of serum estradiol, progesterone and levonorgestrel concentrations. Correlations among these factors and uterine bleeding were calculated. Proliferative endometrium (but not sex steroid levels) was associated with abnormal bleeding. Neither ovarian steroid nor levonorgestrel concentrations was a predictor of abnormal bleeding. Hyperplastic changes were not seen even with high estradiol and low levonorgestrel levels.
本研究的目的是确定血清雌二醇、孕酮和左炔诺孕酮浓度与长期使用Norplant植入剂相关的子宫内膜组织学及子宫出血之间的相关性。18名使用Norplant植入剂达五年的使用者接受了子宫内膜活检，并测定了血清雌二醇、孕酮和左炔诺孕酮浓度。计算了这些因素与子宫出血之间的相关性。增殖期子宫内膜（而非性类固醇水平）与异常出血相关。卵巢类固醇和左炔诺孕酮浓度均不是异常出血的预测指标。即使在雌二醇水平高而左炔诺孕酮水平低的情况下，也未观察到增生性改变。
