Strian F, Klicpera C, Caspar F
Arch Psychiatr Nervenkr (1970). 1977 May 16;223(3):203-18. doi: 10.1007/BF00342338.
Psychophysiologic parameters were investigated in 10 patients with endogenous depression during the course of electroconvulsive therapy. Changes in the depressive mood were assessed by the patients at regular intervals using a general mood scale. EEG and heart rate response and habituation were recorded before, during, and after E.C.T. Prior to treatment a low variance and responsiveness and striking intra-individual stability were found in the physiologic parameters. At the start of E.C.T. there was a significant increase in the deviation values of heart rate and a significant increase in the occurrence of typical biphasic heart rate responses. The EEG showed increased amplitudes and a slowing of background activity. Treatment-dependent differences were also seen in the habituation of the EEG amplitude response. Regarding improvement in the depressive mood, differences were found between the retarded and the agitated patients. Agitated patients demonstrated a continous gradual decline of their depressive condition, while in retarded patients the general trend toward improvement passed through a period of increased mood lability. The results are interpreted with reference to the activation dependency of heart rate responses.
对10例内源性抑郁症患者在电休克治疗过程中的心理生理参数进行了研究。患者定期使用一般情绪量表评估抑郁情绪的变化。在电休克治疗前、治疗期间和治疗后记录脑电图（EEG）、心率反应及习惯化情况。治疗前，生理参数存在低变异性和反应性以及显著的个体内稳定性。在电休克治疗开始时，心率偏差值显著增加，典型双相心率反应的发生率显著增加。脑电图显示振幅增加，背景活动减慢。脑电图振幅反应的习惯化也存在治疗依赖性差异。关于抑郁情绪的改善，在迟滞型和激越型患者之间发现了差异。激越型患者的抑郁状况持续逐渐下降，而在迟滞型患者中，改善的总体趋势经过了情绪不稳定性增加的时期。参考心率反应的激活依赖性对结果进行了解释。
