Weissbach G, Domula M, Lenk H, Rogos R
Folia Haematol Int Mag Klin Morphol Blutforsch. 1979;106(1):89-102.
In 70 newborns with respiratory distress syndrome (RDS) and in roughly the same number of eutrophic mature newborns the total antiplasmin, progressive antithrombin and alpha 2-macroglobulin was determined, the latter in an enzymatical as well as immunochemical way. In healthy mature newborns the progressive antithrombin was somewhat below the level of adults, alpha 2-macroglobulin was above it in both methods and total antiplasmin within it. All parameters of protease inhibitory capacity were significantly lowered in newborns with RDS. Smaller values could be found in patients with bleedings and in those who died later on. Even in those patients with a birth weight under 2,000 g there was a tendency to lower values which can only be partially due to the specificity of development of inhibitors. Progressive antithrombin, total antiplasmin and alpha 2-macroglobulin determined enzymatically are correlated in newborns with RDS jointly and with numerous other parameters of the coagulation system. These relations point to the fact that all components are included in the same consumption process, viz. in the process of disseminated intravascular coagulation. Alpha 2-macroglobulin values determined immunochemically do not correlate with coagulation parameters determined enzymatically as well as with other parameters. They lay partially above or below those determined enzymatically. This behaviour can only be explained by a partial enzyme complex binding of alpha 2-macroglobulin in newborns with RDS.
对70例患有呼吸窘迫综合征（RDS）的新生儿以及数量大致相同的营养良好的成熟新生儿，测定了总抗纤溶酶、活性抗凝血酶和α2-巨球蛋白，后者采用酶法和免疫化学法进行测定。在健康成熟新生儿中，活性抗凝血酶略低于成人水平，α2-巨球蛋白在两种方法测定中均高于成人水平，总抗纤溶酶则处于成人水平范围内。RDS新生儿的蛋白酶抑制能力的所有参数均显著降低。有出血症状的患者以及后来死亡的患者数值更低。即使是出生体重低于2000g的患者也有数值降低的趋势，这只能部分归因于抑制剂发育的特殊性。在患有RDS的新生儿中，酶法测定的活性抗凝血酶、总抗纤溶酶和α2-巨球蛋白与凝血系统的许多其他参数共同相关。这些关系表明所有成分都参与了同一个消耗过程，即弥散性血管内凝血过程。免疫化学法测定的α2-巨球蛋白值与酶法测定的凝血参数以及其他参数不相关。它们部分高于或低于酶法测定的值。这种行为只能通过RDS新生儿中α2-巨球蛋白的部分酶复合物结合来解释。
