L-丙氨酸的低酮血症效应。大鼠血液中3-羟基丁酸浓度的特异性降低。
Hypoketonaemic effect of L-alamine. Specific decrease in blood concentrations of 3-hydroxybutyrate in the rat.
作者信息
Ozand P T, Reed W D, Girard J, Hawkins R L, Collins R M, Tildon J T, Cornblath M
出版信息
Biochem J. 1977 Jun 15;164(3):557-64. doi: 10.1042/bj1640557.
Abstract
- The injection of L-alanine (50-100 mg/kg) into 35-day-old rats that had been starveed for 48 h increased blood L-alanine concentration to values observed in fed animals and lowered the blood concentration of 3-hydroxybutyrate within 2 min. 2. This hypoketon aemic action of L-alanine was specific for 3-hydroxybutyrate, since the acetoacetate concentrations did not change significantly. 3. The decrease in 3-hydroxybutyrate elicited by L-alanine was not related to changes in the blood concentrations of insulin, glucagon, growth hormone, glucose, unesterified fatty acids, lactate or pyruvate. 4. The injection of L-alanine resulted in a decrease in total ketones that was apparently unrelated to their increased peripheral utilization. These results are interpreted as an anti-ketogenic action of L-alanine. 5. The data suggest that L-alamine lowers ketone-body formation in starved rats, possibly via an alteration in hepatic redox equilibrium.
摘要
- 给饥饿48小时的35日龄大鼠注射L-丙氨酸（50 - 100毫克/千克），可使血液中L-丙氨酸浓度升高至喂食动物的水平，并在2分钟内降低血液中3-羟基丁酸酯的浓度。2. L-丙氨酸的这种低酮血症作用对3-羟基丁酸酯具有特异性，因为乙酰乙酸浓度没有显著变化。3. L-丙氨酸引起的3-羟基丁酸酯减少与胰岛素、胰高血糖素、生长激素、葡萄糖、未酯化脂肪酸、乳酸或丙酮酸的血液浓度变化无关。4. 注射L-丙氨酸导致总酮类减少，这显然与其外周利用率增加无关。这些结果被解释为L-丙氨酸的抗生酮作用。5. 数据表明，L-丙氨酸可能通过改变肝脏氧化还原平衡降低饥饿大鼠体内酮体的形成。
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