胰岛素和胰高血糖素对酮体周转的影响。
The effects of insulin and glucagon on ketone-body turnover.
作者信息
Reed W D, Baab P J, Hawkins R L, Ozand P T
出版信息
Biochem J. 1984 Jul 15;221(2):439-44. doi: 10.1042/bj2210439.
A double-isotope procedure was used to measure the effects of insulin and glucagon on ketone-body production and utilization (i.e. turnover) in the starved rat. Somatostatin was infused during the experiment to suppress the pancreatic release of either hormone. The immediate action of insulin in terms of ketone-body turnover that was most evident was a decreased production of 3-hydroxybutyrate, with no significant change in the turnover of acetoacetate. Similarly, the significant effect of glucagon infusion was to increase the production of 3-hydroxybutyrate, with minimum increase in acetoacetate turnover. The data support a direct effect of both hormones on the distribution of acetyl units derived from fatty acid beta-oxidation.
采用双同位素法来测定胰岛素和胰高血糖素对饥饿大鼠酮体生成和利用（即周转）的影响。实验期间输注生长抑素以抑制这两种激素的胰腺释放。就酮体周转而言，胰岛素最明显的即时作用是3-羟基丁酸生成减少，而乙酰乙酸周转无显著变化。同样，输注胰高血糖素的显著作用是增加3-羟基丁酸的生成，而乙酰乙酸周转增加最少。这些数据支持这两种激素对源自脂肪酸β氧化的乙酰单位分布有直接影响。
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