Karasulu H Y, Ertan G, Köse T, Günerí T
Pharmaceutical Technology Department, Faculty of Pharmacy, University of Ege, Izmir, Turkey.
Eur J Drug Metab Pharmacokinet. 1996 Jan-Mar;21(1):27-31. doi: 10.1007/BF03190275.
In our recent study, a new sustained release dosage form of nitrofurantoin (nft) as matrix tablets by 2(2) factorial design has been prepared by using different drug:polymer ratios. The effect of the polyvinylpyrolidone contents of nft matrix tablets on dissolution rate and bioavailability of the drug have been evaluated. The ideal formulation which fitted at USP XXII dissolution norms was tested by in vivo experiments. The satisfactory correlation was also obtained between the in vivo and the in vitro results. This study suggested that the amounts of nft excreted in urine can be calculated by using in vitro dissolution results and sampling time.
在我们最近的研究中，通过2（2）析因设计，使用不同的药物与聚合物比例制备了一种新的呋喃妥因（nft）缓释剂型——骨架片。评估了nft骨架片中聚乙烯吡咯烷酮含量对药物溶出速率和生物利用度的影响。对符合美国药典XXII溶出标准的理想制剂进行了体内实验。体内和体外结果之间也获得了令人满意的相关性。本研究表明，可通过体外溶出结果和取样时间来计算尿液中排泄的nft量。
