Markowska A, Macchi C, Nussdorfer G G, Malendowicz L K
Department of Histology and Embryology, School of Medicine, Poznan, Poland.
Histol Histopathol. 1996 Jul;11(3):583-5.
Pneumadin (PNM) is a biologically active decapeptide, originally isolated from mammalian lungs, that has been previously found to acutely stimulate pituitary-adrenocortical axis in rats. The effects of 2-day PNM administration on the atrophic adrenal cortices of rats treated for 8 days with dexamethasone (DX) were investigated. PNM significantly raised adrenal weight and the average volume of adrenocortical cells. The decapeptide strikingly increased ACTH plasma concentration; however, the blood levels of aldosterone and corticosterone, as well as steroid output by adrenal quarters were not apparently affected. In light of these findings the following conclusions can be drawn: (i) PNM enhances the growth of adrenal cortex in DX-administered rats by a mechanism involving the stimulation of ACTH release; and (ii) PNM treatment is probably too short to allow DX-atrophied adrenocortical cells to re-acquire all their differentiated secretory capacities.
肺动素（PNM）是一种具有生物活性的十肽，最初从哺乳动物肺中分离出来，此前已发现它能急性刺激大鼠的垂体 - 肾上腺皮质轴。研究了连续2天给予PNM对用 dexamethasone（DX）治疗8天的大鼠萎缩肾上腺皮质的影响。PNM显著增加了肾上腺重量和肾上腺皮质细胞的平均体积。该十肽显著提高了促肾上腺皮质激素（ACTH）的血浆浓度；然而，醛固酮和皮质酮的血液水平以及肾上腺各部分的类固醇产量并未受到明显影响。根据这些发现可以得出以下结论：（i）PNM通过刺激ACTH释放的机制增强了DX处理大鼠的肾上腺皮质生长；（ii）PNM治疗时间可能太短，无法使DX萎缩的肾上腺皮质细胞重新获得其所有分化的分泌能力。
