Roman J
Department of Medicine, Atlanta Veterans Affairs Medical Center, GA 30033, USA.
Immunol Res. 1996;15(2):163-78. doi: 10.1007/BF02918505.
Lung injury triggers an acute inflammatory response characterized by increased expression and deposition of extracellular matrix (ECM) components such as fibronectin and collagen. Although the function of newly deposited matrices in injured lungs is unknown, their ability to affect the migration, proliferation, differentiation, and activation state of cells in vitro suggests an important role in the initiation and maintenance of the inflammatory response in vivo. Interactions between immune and nonimmune cells with the lung ECM are mediated via cell surface receptors of the integrin family which link the ECM with intracellular molecules involved in signal transduction. Activation of integrin-mediated intracellular signals may promote inflammation by facilitating leukocyte recruitment and cytokine expression.
肺损伤引发急性炎症反应，其特征是细胞外基质（ECM）成分如纤连蛋白和胶原蛋白的表达增加及沉积。尽管损伤肺中新生沉积基质的功能尚不清楚，但它们在体外影响细胞迁移、增殖、分化和激活状态的能力表明其在体内炎症反应的启动和维持中起重要作用。免疫细胞和非免疫细胞与肺ECM之间的相互作用是通过整合素家族的细胞表面受体介导的，这些受体将ECM与参与信号转导的细胞内分子联系起来。整合素介导的细胞内信号激活可能通过促进白细胞募集和细胞因子表达来促进炎症。
