Makiyama K, Ishida K, Zea-Iriarte W, Itsuno M, Yamakawa M, Mori N
Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
J Gastroenterol Hepatol. 1996 Jul;11(7):692-5. doi: 10.1111/j.1440-1746.1996.tb00316.x.
A case of Hippocratic digital associated with secondary hypertrophic osteoarthropathy complicating Crohn's disease in a 29 year old Japanese male is reported. Hippocratic digital, or finger clubbing, complicating inflammatory bowel disease has been frequently reported in the Western hemisphere. However, its association with secondary hypertrophic osteoarthropathy has been very rarely found in that disease. In Japan, Hippocratic digital has not been described previously. With regard to the pathogenesis of Hippocratic digital and secondary hypertrophic osteoarthropathy, the theory that both entities belong to the same pathological spectrum and that megakaryocytes or platelet clumps may play the most important role, is discussed.
报告了一例29岁日本男性患希波克拉底面征（杵状指）并伴有继发性肥大性骨关节病，该病症使克罗恩病复杂化。在西半球，希波克拉底面征（杵状指）并发炎症性肠病的情况屡有报道。然而，在该疾病中其与继发性肥大性骨关节病的关联却极为罕见。在日本，此前尚未有希波克拉底面征（杵状指）的相关描述。关于希波克拉底面征（杵状指）和继发性肥大性骨关节病的发病机制，文中讨论了这样一种理论，即这两种病症属于同一病理范畴，且巨核细胞或血小板团块可能起着最为重要的作用。
