Govan J R, Deretic V
Department of Medical Microbiology, University of Edinburgh Medical School, Scotland.
Microbiol Rev. 1996 Sep;60(3):539-74. doi: 10.1128/mr.60.3.539-574.1996.
Respiratory infections with Pseudomonas aeruginosa and Burkholderia cepacia play a major role in the pathogenesis of cystic fibrosis (CF). This review summarizes the latest advances in understanding host-pathogen interactions in CF with an emphasis on the role and control of conversion to mucoidy in P. aeruginosa, a phenomenon epitomizing the adaptation of this opportunistic pathogen to the chronic chourse of infection in CF, and on the innate resistance to antibiotics of B. cepacia, person-to-person spread, and sometimes rapidly fatal disease caused by this organism. While understanding the mechanism of conversion to mucoidy in P. aeruginosa has progressed to the point where this phenomenon has evolved into a model system for studying bacterial stress response in microbial pathogenesis, the more recent challenge with B. cepacia, which has emerged as a potent bona fide CF pathogen, is discussed in the context of clinical issues, taxonomy, transmission, and potential modes of pathogenicity.
铜绿假单胞菌和洋葱伯克霍尔德菌引起的呼吸道感染在囊性纤维化（CF）的发病机制中起主要作用。本综述总结了在理解CF中宿主-病原体相互作用方面的最新进展，重点关注铜绿假单胞菌向黏液样转变的作用和控制，这一现象体现了这种机会致病菌对CF慢性感染病程的适应，以及洋葱伯克霍尔德菌的固有抗生素耐药性、人传人传播，以及该菌有时导致的快速致死性疾病。虽然对铜绿假单胞菌向黏液样转变机制的理解已发展到这一现象已演变成研究微生物发病机制中细菌应激反应的模型系统的程度，但作为一种真正的强效CF病原体而出现的洋葱伯克霍尔德菌最近带来的挑战，将在临床问题、分类学、传播和潜在致病模式的背景下进行讨论。
