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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Isab A A, Sadler P J

Biochim Biophys Acta. 1977 Jun 24;492(2):322-30. doi: 10.1016/0005-2795(77)90083-6.

Addition of Au(III) (as chloroaurate) to folded ribonuclease A causes the formation of aggregates, as shown by chromatography and extreme broadening of the 270 MHZ 1H NMR spectrum. 2. When RNAase is partially unfolded Au(III) causes oxidation of methionines to the sulphoxide, and leads to almost complete unfolding (at molar equivalent ratios). 3. Reactions between model methionine derivatives and Au(III) show that the oxidation involves the production of Au(I)-methionine species. The stability of these complexes is dependent on the availability of free NH2 groups which catalyse their disproportionation.

向折叠的核糖核酸酶A中添加Au(III)（以氯金酸盐形式）会导致聚集体形成，这通过色谱法以及270兆赫兹1H NMR谱的极度展宽得以证明。2. 当核糖核酸酶部分展开时，Au(III)会使甲硫氨酸氧化为亚砜，并导致几乎完全展开（在摩尔当量比下）。3. 模型甲硫氨酸衍生物与Au(III)之间的反应表明，氧化过程涉及Au(I)-甲硫氨酸物种的产生。这些配合物的稳定性取决于催化其歧化反应的游离NH2基团的可用性。

Isab A A, Sadler P J

Biochim Biophys Acta. 1977 Jun 24;492(2):322-30. doi: 10.1016/0005-2795(77)90083-6.

Addition of Au(III) (as chloroaurate) to folded ribonuclease A causes the formation of aggregates, as shown by chromatography and extreme broadening of the 270 MHZ 1H NMR spectrum. 2. When RNAase is partially unfolded Au(III) causes oxidation of methionines to the sulphoxide, and leads to almost complete unfolding (at molar equivalent ratios). 3. Reactions between model methionine derivatives and Au(III) show that the oxidation involves the production of Au(I)-methionine species. The stability of these complexes is dependent on the availability of free NH2 groups which catalyse their disproportionation.

向折叠的核糖核酸酶A中添加Au(III)（以氯金酸盐形式）会导致聚集体形成，这通过色谱法以及270兆赫兹1H NMR谱的极度展宽得以证明。2. 当核糖核酸酶部分展开时，Au(III)会使甲硫氨酸氧化为亚砜，并导致几乎完全展开（在摩尔当量比下）。3. 模型甲硫氨酸衍生物与Au(III)之间的反应表明，氧化过程涉及Au(I)-甲硫氨酸物种的产生。这些配合物的稳定性取决于催化其歧化反应的游离NH2基团的可用性。