Nikolić-Vukosavljević D, Vasiljević N, Branković-Magić M, Polić D
Institute of Oncology and Radiology of Serbia, Department of Experimental and Clinical Oncology, Belgrade, Yugoslavia.
Neoplasma. 1996;43(3):163-9.
Variations in steroid hormone receptor contents throughout age and menopausal periods define three breast carcinoma groups: younger premenopausal carcinomas (aged up to 45), middle-aged carcinomas (pre-, peri- and postmenopausal aged 45-59) and older postmenopausal carcinomas (aged over 59). Age-related steroid hormone receptor contents within premenopausal and postmenopausal carcinoma groups are characterized by the important increase of both receptor contents, while menopausal-related steroid hormone receptor contents within middle-aged carcinoma group (aged 45-59) are characterized by the important decrease of progesterone receptor content and estrogen receptor functionality. No variations in steroid hormone receptor contents throughout menstrual cycle within the follicular and the luteal phases were obtained. The important decrease of estrogen receptor content in the mid-cycle phase versus the perimenstrual phase was found. Variations in steroid hormone receptor contents throughout age and menopausal periods, as well as throughout menstrual cycle could not be associated with variations in the blood steroid hormone concentrations. However, important association between steroid hormone receptor contents and the blood steroid hormone concentrations was found within the luteal phase carcinoma group and within older postmenopausal carcinoma group. It is interesting that within carcinoma group with the highest concentration of progesterone, progesterone receptor content increases with an increase of the ratio of estradiol and progesterone blood concentrations, while within carcinoma group with the lowest steroid hormone concentration and the highest content of estrogen receptor content, estrogen receptor content decreases with an increase of either the blood estradiol concentration or the ratio of the blood estradiol and progesterone blood concentrations.
年轻的绝经前乳腺癌（年龄在45岁及以下）、中年乳腺癌（绝经前、围绝经期和绝经后，年龄在45 - 59岁）以及老年绝经后乳腺癌（年龄超过59岁）。绝经前和绝经后乳腺癌组内与年龄相关的甾体激素受体含量的特征是两种受体含量均显著增加，而中年乳腺癌组（年龄45 - 59岁）内与绝经相关的甾体激素受体含量的特征是孕激素受体含量显著降低以及雌激素受体功能降低。在卵泡期和黄体期整个月经周期内未发现甾体激素受体含量有变化。发现月经周期中期相对于月经前期雌激素受体含量显著降低。整个年龄和绝经期间以及整个月经周期内甾体激素受体含量的变化与血液甾体激素浓度的变化无关。然而，在黄体期乳腺癌组和老年绝经后乳腺癌组内发现了甾体激素受体含量与血液甾体激素浓度之间的重要关联。有趣的是，在孕激素浓度最高的癌组内，孕激素受体含量随着雌二醇与孕激素血液浓度比值的增加而增加，而在甾体激素浓度最低且雌激素受体含量最高的癌组内，雌激素受体含量随着血液雌二醇浓度或血液雌二醇与孕激素血液浓度比值的增加而降低。
