氘代7-(5'-脱氧-5'-甲基硫代-β-D-呋喃核糖基)腺嘌呤-d3的合成
Synthesis of deuterated 7-(5'-deoxy-5'-methylthio-beta-D-ribofuranosyl)adenine-d3.
作者信息
Sugiyama T, Yamashita M
机构信息
Department of Agricultural Chemistry, Meiji University, Kanagawa, Japan.
出版信息
Nucleic Acids Symp Ser. 1995(34):13-4.
PMID:8841528
Abstract
Synthesis of 7-(5'-deoxy-5'-methyl-thio-beta-D-ribofuranosyl)-adenine(7-MTA) has been developed from imidazole through 7-beta -D-ribofuranosyladenine. Deuterated 7-MTA-d3 was also synthesized by this synthetic procedure using deuterium labelled dimethyl disulfide-d6. The deuterium content of 7-MTA-d3 was 98.28%. The spectral and chemical properties of 7-MTA were defined.
摘要
7-(5'-脱氧-5'-甲基硫代-β-D-呋喃核糖基)-腺嘌呤（7-MTA）已由咪唑通过7-β-D-呋喃核糖基腺嘌呤合成。使用氘标记的二甲基二硫-d6，通过该合成方法也合成了氘代7-MTA-d3。7-MTA-d3的氘含量为98.28%。确定了7-MTA的光谱和化学性质。
Zotero 插件