含碳环核苷的寡核苷酸的合成。
Synthesis of oligonucleotides containing a carbocyclic nucleoside.
作者信息
Komeda Y, Sakata K, Sugiyama H, Saito I
机构信息
Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Japan.
出版信息
Nucleic Acids Symp Ser. 1995(34):43-4.
PMID:8841543
Abstract
2'-Bromo-substituted cyclopentane-type carbocyclic nucleoside (7a, 7b) was synthesized from sodium cyclopentadienylide. Subsequently, 7a was incorporated into DNA oligomer by means of a conventional phosphoramidite method. Melting-temperature, CD spectra and chemical reaction of such carbocyclic oligonucleotide are described.
摘要
由环戊二烯基钠合成了2'-溴取代的环戊烷型碳环核苷（7a，7b）。随后，通过常规亚磷酰胺法将7a掺入DNA寡聚物中。描述了这种碳环寡核苷酸的熔解温度、圆二色光谱和化学反应。
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