Ide H, Ikeda H, Makino K, Sasaki M, Sugimoto N
Department of Polymer Science and Engineering, Kyoto Institute of Technology, Japan.
Nucleic Acids Symp Ser. 1995(34):81-2.
The alpha-anomer of 2'-deoxyadenosine (alpha) is a major adenine lesion produced by hydroxyl radicals. This lesion was specifically incorporated in duplexes d(TGAGXGTAC).d(GTACNCTCA), where X = alpha and N = A, G, C, or T. The thermodynamic and structural perturbations introduced into DNA by alpha were assessed by UV-melting measurements and molecular mechanics calculations.
