蒽醌-甘氨酸和蒽醌-亚氨基二乙酸共轭物对酵母苯丙氨酸tRNA的位点特异性水解作用。

Site-specific hydrolysis of yeast tRNAPhe by anthraquinone-glycine and anthraquinone-iminodiacetate conjugates.

作者信息

Endo M, Hirata K, Inokawa T, Matsumura K, Komiyama M, Ihara T, Sueda S, Takagi M

机构信息

Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, Japan.

出版信息

Nucleic Acids Symp Ser. 1995(34):109-10.

PMID:8841576

Abstract

Site-specific hydrolysis of yeast tRNAPhe was performed by anthraquinone-glycine conjugate (Anth-Gly) and anthraquinone-iminodiacetate conjugate (Anth-IDA) under physiological conditions. The cleavages by Anth-Gly occurred selectively at the stems, whereas the cleavage by Anth-IDA are restricted to the D-loop, the extra-loop, and the T psi C-stem.

摘要

在生理条件下，通过蒽醌 - 甘氨酸共轭物（Anth - Gly）和蒽醌 - 亚氨基二乙酸共轭物（Anth - IDA）对酵母苯丙氨酸转运核糖核酸（tRNAPhe）进行位点特异性水解。Anth - Gly引起的切割选择性地发生在茎区，而Anth - IDA引起的切割则局限于D环、额外环和TψC茎区。