肽异二聚体对序列特异性DNA的识别
Sequence-specific DNA recognition by peptide heterodimers.
作者信息
Sawada M, Aizawa Y, Ueno M, Morii T, Sugiura Y
机构信息
Institute for Chemical Research, Kyoto University, Japan.
出版信息
Nucleic Acids Symp Ser. 1995(34):141-2.
The DNA binding motif rich in basic amino acid residues is used by a variety of DNA binding proteins to recognize specific DNA sequences. We report here a sequence-specific DNA recognition by peptide heterodimers derived from the basic leucine zipper proteins. Specific hetero-dimerization is controlled by an artificial dimerization module consisting of a host-guest inclusion complex. Efficiency of the sequence discrimination by the peptide dimers depends on a stability of the half-matched binding complex. However, structures of the matched and half-matched binding complexes differ from one another.
富含碱性氨基酸残基的DNA结合基序被多种DNA结合蛋白用于识别特定的DNA序列。我们在此报告了源自碱性亮氨酸拉链蛋白的肽异二聚体对序列特异性的DNA识别。特异性异二聚化由一个由主客体包合物组成的人工二聚化模块控制。肽二聚体对序列区分的效率取决于半匹配结合复合物的稳定性。然而，匹配和半匹配结合复合物的结构彼此不同。
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