Fuglum E, Rosenberg C, Damsbo N, Stage K, Lauritzen L, Bech P
Kongensgata 27C, Moss, Norway.
Acta Psychiatr Scand. 1996 Jul;94(1):18-25. doi: 10.1111/j.1600-0447.1996.tb09819.x.
This study is a comparison across treatment settings of two previously published trials, namely the Danish University Antidepressant Group (DUAG) study on citalopram vs. clomipramine in hospitalized patients with major depression, and the Nordic citalopram vs. imipramine study of depressed patients treated by their family doctors. The Hamilton Depression Scale (HAM-D) had the same level of inter-rater reliability and construct validity in the two settings. Using a HAM-D score of 7 or less as the criterion for full two remission, clomipramine was superior to imipramine and citalopram. Using a reduction of the baseline HAM-D score by 50% or more as a response criterion, there were no differences between the three antidepressants after 5 or 6 weeks of treatment. Citalopram showed superior tolerability to the tricyclic antidepressants.
本研究对两个先前发表的试验的治疗环境进行了比较，即丹麦大学抗抑郁药组（DUAG）关于西酞普兰与氯米帕明治疗重度抑郁症住院患者的研究，以及北欧关于家庭医生治疗的抑郁症患者中西酞普兰与丙咪嗪的研究。汉密尔顿抑郁量表（HAM-D）在两种环境下具有相同水平的评分者间信度和结构效度。以HAM-D评分为7或更低作为完全缓解的标准，氯米帕明优于丙咪嗪和西酞普兰。以基线HAM-D评分降低50%或更多作为反应标准，治疗5或6周后三种抗抑郁药之间没有差异。西酞普兰显示出比三环类抗抑郁药更好的耐受性。
