Piérard G E, Arrese J E, Piérard-Franchimont C
Department of Dermatopathology, University of Liège, Belgium.
Drugs. 1996 Aug;52(2):209-24. doi: 10.2165/00003495-199652020-00005.
Superficial fungal infections affect millions of people throughout the world. Among them, tinea represents cutaneous infections by dermatophytes. Therapeutic strategies depend upon the affected body site. Hence, clinicians distinguish several types of tinea including the corporis, faciei, cruris, pedis, manuum, capitis, barbae and unguium variants. There are several ways of tackling the tinea problem. Numerous topical and oral antifungals are available today. Topical antifungals remain the most commonly recommended treatment for many superficial dermatophytoses. Active compounds include imidazoles, morpholines and allylamines, with a few other miscellaneous drugs. The recent development of new generation oral agents (fluconazole, itraconazole, terbinafine) has enhanced the armamentarium against difficult-to-treat tineas. The antifungal efficacy and pharmacokinetic profiles of these drugs allow shorter durations of treatment and the innovative use of intermittent pulse regimens. The modern formulations fully meet the requirements of being well tolerated, involving little risk and acting specifically against relevant pathogens. However, the response rates to date do not always come up to the high expectations offered by in vitro studies.
浅表真菌感染影响着全球数百万人。其中，癣是由皮肤癣菌引起的皮肤感染。治疗策略取决于感染的身体部位。因此，临床医生区分了几种类型的癣，包括体癣、面癣、股癣、足癣、手癣、头癣、须癣和甲癣变种。有几种方法可以解决癣的问题。如今有许多局部和口服抗真菌药物。局部抗真菌药物仍然是许多浅表皮肤癣菌病最常用的推荐治疗方法。活性化合物包括咪唑类、吗啉类和烯丙胺类，还有一些其他杂类药物。新一代口服药物（氟康唑、伊曲康唑、特比萘芬）的最新发展增强了对抗难治性癣的武器库。这些药物的抗真菌疗效和药代动力学特征允许缩短治疗时间，并创新性地使用间歇性脉冲疗法。现代制剂完全满足耐受性良好、风险小且能特异性对抗相关病原体的要求。然而，迄今为止的有效率并不总是能达到体外研究提出的高期望。
