Khor E, Tay L F, Goh K S, Lee C N
Department of Chemistry, National University of Singapore, Kent Ridge, Singapore.
Biomaterials. 1996 Aug;17(16):1631-7. doi: 10.1016/0142-9612(95)00317-7.
A novel drug delivery system was developed for the treatment of prosthetic valve endocarditis (PVE). The antibiotic, gentamicin, was impregnated into surgical pledgets using non-solvent coacervation of polylactic acid (PLA) as a binding/encapsulating agent. The in vitro dissolution profiles show controlled release of gentamicin for up to 36 h when PLA of molecular weight 2000 is used and up to 7 d for PLA with a molecular weight of 50,000. The results indicate potential for the localized treatment of PVE, which is cost-effective, easy to manufacture and permits dosage variability.
一种用于治疗人工瓣膜心内膜炎（PVE）的新型药物递送系统被开发出来。使用聚乳酸（PLA）的非溶剂凝聚作为结合/包封剂，将抗生素庆大霉素浸渍到手术用棉垫中。体外溶出曲线表明，当使用分子量为2000的PLA时，庆大霉素可控制释放长达36小时；当使用分子量为50000的PLA时，可控制释放长达7天。结果表明该系统在PVE局部治疗方面具有潜力，其具有成本效益、易于制造且允许剂量变化。
