Saakov B A, Khoruzhaia T A, Bardakhch'ian E A
Biull Eksp Biol Med. 1977 May;83(5):606-10.
The effect of serotonin on dog white matter ultrastructure in the CNS was investigated. The intracysternal injection of this amine (6 microgram in 0.1 ml of physiological saline) induced significant lesions in the myelin and glia of the spinal cord white matter areas adjacent to the cerebrospinal fluid tracts. A loss of the regular structure and stratification of the myelin lamellae, as well as rupture and lysis of the myelin membranes, and their demyelination occurred. There was vacuolar dystrophy of oligodendrocytes; the astrocytes remained practically unchanged. After local intracranial injection of this amine (2 microgram in 0.01 ml of physiological saline) similar lesions were observed in the white matter of the cerebral hemisphere; in addition signs of inflammatory reaction were revealed at the late period of investigation. In control animals injected with physiological saline the changes were observed later and in gliocytes only. A conclusion was drawn that serotonin was capable of injuring the myelin and glia.
研究了血清素对中枢神经系统中犬白质超微结构的影响。向脑池内注射这种胺（6微克溶于0.1毫升生理盐水中）会在与脑脊液通道相邻的脊髓白质区域的髓磷脂和神经胶质中引起明显损伤。髓磷脂板层的规则结构和分层丧失，以及髓磷脂膜的破裂、溶解及其脱髓鞘现象均会出现。少突胶质细胞出现空泡性营养不良；星形胶质细胞基本保持不变。在颅内局部注射这种胺（2微克溶于0.01毫升生理盐水中）后，在大脑半球白质中观察到类似损伤；此外，在研究后期还发现了炎症反应迹象。在注射生理盐水的对照动物中，变化出现得较晚，且仅见于神经胶质细胞。得出的结论是血清素能够损伤髓磷脂和神经胶质。
