Matsumoto S
Department of Physiology, Nippon Dental University, Tokyo, Japan.
Lung. 1996;174(5):333-44. doi: 10.1007/BF00176192.
An in vivo preparation was designed to investigate the effect of vagus nerve stimulation-induced bronchoconstriction on the relationship of slowly adapting pulmonary stretch receptor (SAR) activity and lung mechanics. SAR activities were recorded from the left vagus nerve. The responses of SARs, total lung resistance (RL), and dynamic lung compliance (Cdyn) to electrical stimulation of the peripheral end of the cut right vagus nerve (10-15 V, 5-30 Hz, 0.2 ms) were examined before atropine and 5 and 10 min after atropine (2 mg/kg) in anesthetized, artificially ventilated, bilaterally vagotomized rabbits. In the time course profile during vagal stimulation, an increase in RL and a decrease in Cdyn occurred simultaneously, and these opposite changes were frequency dependent. The average responses of SAR activity, RL, and Cdyn to vagal stimulation became more pronounced as the frequencies of the stimulation were increased. The responses obtained during vagal stimulation (5-30 Hz) were blocked or diminished greatly by the administration of atropine. Repeated vagus nerve stimulation in the presence of atropine did not show any significant change in SAR activity and lung mechanics. These results suggest that changes of SAR activity, RL, and Cdyn induced by vagal stimulation occur as a result of smooth muscle contraction in the airways, which is mediated mainly by muscarinic receptor activation and which is not involved in the release of neurotransmitters to relax airway smooth muscle.
设计了一种体内实验准备，以研究迷走神经刺激诱导的支气管收缩对慢适应性肺牵张感受器（SAR）活动与肺力学关系的影响。从左迷走神经记录SAR活动。在麻醉、人工通气、双侧迷走神经切断的兔中，在给予阿托品前以及给予阿托品（2mg/kg）后5分钟和10分钟，检查SAR、总肺阻力（RL）和动态肺顺应性（Cdyn）对切断的右迷走神经外周端电刺激（10 - 15V，5 - 30Hz，0.2ms）的反应。在迷走神经刺激的时间进程中，RL增加和Cdyn降低同时发生，并且这些相反的变化与频率相关。随着刺激频率增加，SAR活动、RL和Cdyn对迷走神经刺激的平均反应变得更加明显。在迷走神经刺激（5 - 30Hz）期间获得的反应在给予阿托品后被阻断或大大减弱。在阿托品存在下重复迷走神经刺激未显示SAR活动和肺力学有任何显著变化。这些结果表明，迷走神经刺激诱导的SAR活动、RL和Cdyn的变化是气道平滑肌收缩的结果，其主要由毒蕈碱受体激活介导，并且不涉及神经递质释放以舒张气道平滑肌。
