氯化钾诱导大鼠肛门尾骨肌松弛的性质。
The nature of potassium chloride-induced relaxations of the rat anococcygeus muscle.
作者信息
Gibson A, James T A
出版信息
Br J Pharmacol. 1977 May;60(1):141-5. doi: 10.1111/j.1476-5381.1977.tb16758.x.
Abstract
- The nature of KCl-induced relaxations of the rat anococcygeus muscle was investigated. 2. The relaxations were mimicked by other K+ salts, but not by NaCl. 3. The muscle was more susceptible to the relaxant effects of KCl than the contractile effects. 4. Addition of ouabain (100 micron) had no effect on the relaxations. 5. The relaxations were abolished by tetrodotoxin (5 microgram/ml), procaine (500 micron), and by section of the inhibitory nerves. 6. The results suggest that KCl-induced relaxations are due to stimulation of the inhibitory nerves by K+.
摘要
- 研究了氯化钾诱导大鼠肛门尾骨肌松弛的性质。2. 其他钾盐可模拟这种松弛，但氯化钠不能。3. 该肌肉对氯化钾的松弛作用比收缩作用更敏感。4. 添加哇巴因（100微摩尔）对松弛无影响。5. 河豚毒素（5微克/毫升）、普鲁卡因（500微摩尔）以及切断抑制性神经可消除这种松弛。6. 结果表明，氯化钾诱导的松弛是由于钾离子刺激了抑制性神经。
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