免疫交感神经切除术和6-羟基多巴胺对大鼠肛尾肌对神经刺激及某些药物反应的影响。
The effect of immunosympathectomy and of 6-hydroxydopamine on the responses of the rat anococcygeus to nerve stimulation and to some drugs.
作者信息
Gibson A, Gillespie J S
出版信息
Br J Pharmacol. 1973 Feb;47(2):261-7. doi: 10.1111/j.1476-5381.1973.tb08323.x.
Abstract
- The rat anococcygeus muscle possesses a dense motor adrenergic innervation and also a powerful inhibitory innervation whose transmitter is unknown. The possibility that the adrenergic nerves released both noradrenaline and the unknown inhibitory transmitter was investigated by destroying the adrenergic nerves either by immunosympathectomy or by 6-hydroxydopamine.2. Immunosympathectomy was only partially effective in destroying the adrenergic neurones to the anococcygeus. 6-Hydroxydopamine destroyed the terminal adrenergic varicosities abolishing almost completely the motor response. Neither treatment affected the inhibitory response.3. 6-Hydroxydopamine induced a specific hypersensitivity of the muscle to noradrenaline which was not shared with carbachol.4. The maximum tension response of the anococcygeus muscle was greater in the male than in the female probably because the muscle is bigger.
摘要
大鼠的肛门尾骨肌拥有密集的运动肾上腺素能神经支配，同时还有一种强大的抑制性神经支配，其递质尚不清楚。通过免疫交感神经切除术或6-羟基多巴胺破坏肾上腺素能神经，研究了肾上腺素能神经释放去甲肾上腺素和未知抑制性递质的可能性。
免疫交感神经切除术在破坏支配肛门尾骨肌的肾上腺素能神经元方面仅部分有效。6-羟基多巴胺破坏了终末肾上腺素能曲张体，几乎完全消除了运动反应。两种处理均未影响抑制反应。
6-羟基多巴胺诱导肌肉对去甲肾上腺素产生特异性超敏反应，而对卡巴胆碱无此反应。
肛门尾骨肌的最大张力反应在雄性中比在雌性中更大，可能是因为雄性的肌肉更大。
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Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-Hydroxydopamine.用6-羟基多巴胺选择性破坏肾上腺素能神经末梢进行化学性交感神经切除术。
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