Pallarés I, López-Aliaga I, Lisbona F, Moratalla A, Gómez-Ayala A E, Barrionuevo M, Hartiti S, Alférez M J, Campos M S
Departamento de Fisiología, Facultad de Farmacia, Universidad de Granada, Spain.
Int J Vitam Nutr Res. 1996;66(2):158-65.
We investigated the effect of Fe deficiency on the nutritive utilization of Fe, Ca, P and Mg in rats. Aside from the well known depletion of Fe in liver, femur and sternum with low values of Hb, Fe deficiency impaired Ca, P and Mg metabolism at different degrees. Iron deficiency altered Mg absorption, lowered the concentration of Ca in the liver, femur and sternum, raised the concentration of P and Mg in the liver, and decreased P in the femur. The altered status was not completely rectified by iron supplementation as the animals were still slightly anemic at the end of the study. The second purpose of the study was to evaluate the ability of three iron compounds (ferric citrate, ferrous sulfate and ferrous ascorbate) to correct the undesirable effects of Fe deficiency. Ten days after treatment with these diets, Fe-deficient rats still had reduced Mg absorption, especially those fed ferric citrate. The concentrations of hemoglobin approached normal values in all groups; however, serum Fe remained low, indicating that Fe reserves were still depleted. Hepatic and femoral Fe concentrations were also lower in all Fe-deficient groups regardless of the diet given, compared with their respective controls, whereas Fe concentrations in the sternum increased significantly with all three diets, suggesting an increase in erythropoiesis. The concentration of Ca, P and Mg in liver approached normal values, and appeared to normalize in the femur, except that Ca and P concentrations remained low with the citrate diet. In the sternum, a site assumed to have higher requirements for these minerals, the concentrations of Ca, P and Mg also increased. These findings indicate that Fe is involved in the bone mineralization, and that in physiological terms, Fe interacts favorably with Ca, P and Mg metabolism, since Fe deficiency altered the status of these metals. These findings also suggest that ferrous ascorbate and ferrous sulfate were more effectively absorbed than was ferric citrate.
我们研究了缺铁对大鼠铁、钙、磷和镁营养利用的影响。除了众所周知的肝脏、股骨和胸骨中铁含量减少以及血红蛋白值较低外，缺铁还不同程度地损害了钙、磷和镁的代谢。缺铁改变了镁的吸收，降低了肝脏、股骨和胸骨中钙的浓度，提高了肝脏中磷和镁的浓度，并降低了股骨中磷的浓度。补充铁后，这种改变的状态并未完全纠正，因为在研究结束时动物仍有轻微贫血。该研究的第二个目的是评估三种铁化合物（柠檬酸铁、硫酸亚铁和抗坏血酸亚铁）纠正缺铁不良影响的能力。用这些饮食处理10天后，缺铁大鼠的镁吸收仍然减少，尤其是喂食柠檬酸铁的大鼠。所有组的血红蛋白浓度都接近正常值；然而，血清铁仍然很低，表明铁储备仍然不足。与各自的对照组相比，无论给予何种饮食，所有缺铁组的肝脏和股骨中铁浓度也较低，而胸骨中铁浓度在所有三种饮食下均显著增加，表明红细胞生成增加。肝脏中钙、磷和镁的浓度接近正常值，股骨中的浓度似乎也恢复正常，只是柠檬酸饮食组的钙和磷浓度仍然较低。在胸骨这个被认为对这些矿物质需求较高的部位，钙、磷和镁的浓度也增加了。这些发现表明铁参与了骨矿化，从生理学角度来看，铁与钙、磷和镁的代谢相互作用良好，因为缺铁改变了这些金属的状态。这些发现还表明，抗坏血酸亚铁和硫酸亚铁的吸收比柠檬酸铁更有效。
