限制体外受精/胚胎移植（IVF-ET）周期中的多胎妊娠。
Limiting multiple pregnancy in in vitro fertilization/embryo transfer (IVF-ET) cycles.
作者信息
Austin C M, Stewart S P, Goldfarb J M, Sheean L A, Gindlesperger V R, Duchon M A
机构信息
Department of Obstetrics and Gynecology, University MacDonald Womens Hospital, Cleveland, Ohio, USA.
出版信息
J Assist Reprod Genet. 1996 Aug;13(7):540-5. doi: 10.1007/BF02066605.
PURPOSE
Our purpose was to assess how the number of embryos transferred can be adjusted to limit multiple gestations.
METHODS
A retrospective analysis of 535 consecutive embryo transfers for the years 1991-1993 was conducted.
RESULTS
Fewer than three embryos were associated with a low pregnancy rate. Pregnancy rates were highest in women less than 35 when four or more embryos were transferred. With four or more embryos, multiple gestation pregnancy correlated with the number of high-quality embryos transferred. The risk of triplets and quadruplets was greatest for women less than 40.
CONCLUSIONS
Multiple-embryo transfer carries a risk of plural gestation. The risk of multiple pregnancy cannot be eliminated without decreasing the pregnancy rate. The risk of high-order multiple pregnancy was best correlated with the number of good-quality embryos transferred. While all are at risk, patients younger than 40 were at highest risk.
目的
我们的目的是评估如何调整移植胚胎数量以限制多胎妊娠。
方法
对1991年至1993年连续进行的535例胚胎移植进行回顾性分析。
结果
移植少于三个胚胎与低妊娠率相关。当移植四个或更多胚胎时，年龄小于35岁的女性妊娠率最高。移植四个或更多胚胎时，多胎妊娠与移植的优质胚胎数量相关。年龄小于40岁的女性怀三胞胎和四胞胎的风险最大。
结论
多胚胎移植存在多胎妊娠风险。不降低妊娠率就无法消除多胎妊娠风险。高阶多胎妊娠风险与移植的优质胚胎数量最相关。虽然所有人都有风险，但40岁以下的患者风险最高。
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