Delgrange E, Goethals P, Laka A, Maiter D, Lambert M
Division of General Internal Medicine, Saint-Luc University Hospital, Louvain Medical School, Brussels, Belgium.
J Endocrinol Invest. 1996 Jun;19(6):377-81. doi: 10.1007/BF03344973.
We report the case of a 68-year-old woman presenting with clinical and biochemical evidence of hyperandrogenism. Imaging studies revealed the presence of a bilateral adrenal tumor. Although there was a predominant secretion of androgens, autonomous production of cortisol was also evidenced on the basis of an inversion of the circadian rhythm of plasma cortisol and an absence of cortisol suppression by dexamethasone. The functional status of both tumors was demonstrated by an iodocholesterol scintigraphy and by an adrenal vein catheterization. Surgical excision of both adrenal tumors was performed and histological examination disclosed no criteria of malignancy. The patient still remains disease-free 3 years after surgery. To our knowledge, this is the second report of the bilateral occurrence of a virilizing adrenal tumor and the first in which the functional characteristics of the tumors are detailed.
我们报告了一例68岁女性，其具有高雄激素血症的临床和生化证据。影像学检查显示双侧肾上腺肿瘤。尽管主要分泌雄激素，但基于血浆皮质醇昼夜节律倒置以及地塞米松未能抑制皮质醇分泌，也证明了皮质醇的自主分泌。通过碘胆固醇闪烁扫描和肾上腺静脉插管证实了两个肿瘤的功能状态。对双侧肾上腺肿瘤进行了手术切除，组织学检查未发现恶性标准。术后3年患者仍无疾病复发。据我们所知，这是双侧发生男性化肾上腺肿瘤的第二例报告，也是第一例详细描述肿瘤功能特征的报告。
