苯二氮䓬受体配体对离体大鼠颈上神经节神经元的影响。
Effects of benzodiazepine receptor ligands on isolated rat superior cervical ganglia neurons.
作者信息
Aguayo L G, Cisternas C, Tapia J C, Pancetti F C
机构信息
Laboratory of Neuropharmacology, Catholic University at Valparaiso, Chile.
出版信息
Pharmacology. 1996 Jun;52(6):371-6. doi: 10.1159/000139404.
We studied the effects of diazepam, CL 218,872, Ro 15-1788, beta-CCM and Ro 15-4513 on the gamma-aminobutyric acid-activated current in adult and newborn rat superior cervical ganglion neurons. Diazepam (10-1,000 nmol/l) potentiated the current in a concentration-dependent manner. CL 218,872 was less effective and weaker than diazepam. The other ligands reduced the amplitude of the current. These peripheral receptors might be involved in some of the side effects of benzodiazepines.
我们研究了地西泮、CL 218,872、Ro 15 - 1788、β-CCM和Ro 15 - 4513对成年和新生大鼠颈上神经节神经元中γ-氨基丁酸激活电流的影响。地西泮（10 - 1000纳摩尔/升）以浓度依赖性方式增强电流。CL 218,872的效果和作用强度均低于地西泮。其他配体则降低了电流幅度。这些外周受体可能与苯二氮䓬类药物的某些副作用有关。
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