Freitag J, Krieger J, Strotmann J, Breer H
University Stuttgart-Hohenheim, Institute of Zoophysiology, Stuttgart, Federal Republic of Germany.
Neuron. 1995 Dec;15(6):1383-92. doi: 10.1016/0896-6273(95)90016-0.
Xenopus laevis possess a gene repertoire encoding two distinct classes of olfactory receptors: one class related to receptors of fish and one class similar to receptors of mammals. Sequence comparison indicates that the fish-like receptors represent closely related members of only two subfamilies, whereas mammalian-like receptors are more distantly related, most of them representing a different subfamily. The fish-like receptor genes are exclusively expressed in the lateral diverticulum of the frog's nose, specialized for detecting water-soluble odorants, whereas mammalian-like receptors are expressed in sensory neurons of the main diverticulum, responsible for the reception of volatile odors.
非洲爪蟾拥有一个基因库，该基因库编码两类不同的嗅觉受体：一类与鱼类受体相关，另一类与哺乳动物受体相似。序列比较表明，鱼类样受体仅代表两个亚家族中密切相关的成员，而哺乳动物样受体的亲缘关系较远，其中大多数代表不同的亚家族。鱼类样受体基因仅在蛙鼻的外侧憩室中表达，该区域专门用于检测水溶性气味分子，而哺乳动物样受体则在主要憩室的感觉神经元中表达，负责接收挥发性气味。
