Lyons J M, Ito J I
Department of Infectious Diseases, City of Hope National Medical Center, Duarte, California 91010, USA.
Clin Infect Dis. 1995 Oct;21 Suppl 2:S174-7. doi: 10.1093/clinids/21.supplement_2.s174.
The need to provide women with a partner-independent method of prophylaxis against sexually transmitted disease (STD) against, including Chlamydia trachomatis, has led to a direct effort to develop a vaginally applied, broad-spectrum antimicrobial preparation that is both safe and effective. Using a murine model of C. trachomatis lower genital tract infection, we tested the ability of various vaginally applied chemicals to alter the course of infection in female mice challenged with infectious doses ranging from 10(3) to 10(6) inclusion forming units of an oculogenital serovar of C. trachomatis. When administered in a methylcellulose/propylene glycol-base gel 15 minutes prior to challenge, four widely used topical antimicrobials (benzalkonium chloride, chlorhexidine, nonoxynol-9, and polymyxin B) were shown to protect against infection. These results support the possibility that this type of interventional method may be a clinically relevant means of prophylaxis against sexually transmitted infection with C. trachomatis, the most common bacterial STD agent.
为女性提供一种独立于伴侣的预防包括沙眼衣原体在内的性传播疾病（STD）的方法的需求，促使人们直接致力于开发一种安全有效的经阴道应用的广谱抗菌制剂。利用沙眼衣原体下生殖道感染的小鼠模型，我们测试了各种经阴道应用的化学物质改变感染过程的能力，这些小鼠用沙眼衣原体眼生殖血清型的10³至10⁶个包涵体形成单位的感染剂量进行攻击。在攻击前15分钟以甲基纤维素/丙二醇基凝胶给药时，四种广泛使用的局部抗菌剂（苯扎氯铵、氯己定、壬苯醇醚-9和多粘菌素B）显示出可预防感染。这些结果支持了这种干预方法可能是预防沙眼衣原体性传播感染的一种临床相关手段的可能性，沙眼衣原体是最常见的细菌性性传播疾病病原体。
