生物合成的茶多酚在体外可使沙眼衣原体失活。
Biosynthesized tea polyphenols inactivate Chlamydia trachomatis in vitro.
作者信息
Yamazaki Tsutomu, Kishimoto Toshio, Shiga Sadashi, Sato Kozue, Hagiwara Toshikatsu, Inoue Miyuki, Sasaki Nozomu, Ouchi Kazunobu, Hara Yukihiko
机构信息
Department of Virology 1, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku, Tokyo, Japan 162-8640.
出版信息
Antimicrob Agents Chemother. 2005 Jun;49(6):2501-3. doi: 10.1128/AAC.49.6.2501-2503.2005.
Abstract
Biosynthesized tea polyphenols showed antichlamydial activity against Chlamydia trachomatis D/UW-3/Cx and L2/434/Bu using cell culture. The most active compounds were (-)-epigallocatechin gallate and (-)-epicatechin gallate, followed by (-)-epicatechin (EC). (+)-Epicatechin and (-)-epigallocatechin were intermediate. EC was the least toxic. These results warrant evaluation of tea polyphenols as topical antichlamydial agents.
摘要
利用细胞培养技术，生物合成的茶多酚对沙眼衣原体D/UW-3/Cx和L2/434/Bu显示出抗衣原体活性。活性最强的化合物是（-）-表没食子儿茶素没食子酸酯和（-）-表儿茶素没食子酸酯，其次是（-）-表儿茶素（EC）。（+）-表儿茶素和（-）-表没食子儿茶素活性中等。EC毒性最小。这些结果表明有必要对茶多酚作为局部抗衣原体药物进行评估。
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