Inbar M, Merimsky O, Chaitchik S
Department of Oncology, Tel-Aviv University, Israel.
Anticancer Drugs. 1995 Dec;6(6):775-6. doi: 10.1097/00001813-199512000-00010.
Side effects of cisplatin and carboplatin include nausea, vomiting, peripheral neuropathy, nephrotoxicity, hearing loss, bone marrow depression, and rarely Lhermitte's sign and allergic reactions. A unique case of idiosyncrasy related to carboplatin administration was observed in a young woman treated for ovarian cancer. Symptoms and signs included skin rash, shortness of breath, and redness of face and upper trunk, without drop in blood pressure or change in heart rate, and were resolved within a short time following administration of hydrocortisone and promethazine.
顺铂和卡铂的副作用包括恶心、呕吐、周围神经病变、肾毒性、听力丧失、骨髓抑制，以及罕见的莱尔米特征和过敏反应。在一名接受卵巢癌治疗的年轻女性中观察到了一例与卡铂给药相关的特异反应的独特病例。症状和体征包括皮疹、呼吸急促、面部和上半身发红，血压无下降或心率无变化，在给予氢化可的松和异丙嗪后短时间内症状得到缓解。
