Cole S A, Woodard J L, Juncos J L, Kogos J L, Youngstrom E A, Watts R L
Department of Psychiatry, Emory University School of Medicine, Atlanta, Georgia, USA.
J Neuropsychiatry Clin Neurosci. 1996 Winter;8(1):20-5. doi: 10.1176/jnp.8.1.20.
The relationship between depression and disability in idiopathic Parkinson's disease (PD) was examined in 31 outpatients. Thirteen percent had current major depression (MD), 10% dysthymia, and 32% a lifetime history of MD. Depression was significantly related to both illness severity and functional impairment. Male patients with early-onset PD (before age 55) had more mood and anxiety disorders than late-onset male patients. Patients with right-sided PD had significantly more depressive symptoms than those with left-sided PD. On multiple regression analyses, depression predicted impaired social, role, and physical functioning for men (but not for women), independent of the impact of illness severity. The results suggest that treatment of depression may improve function; however, findings of gender differences will require replication.
对31名门诊特发性帕金森病（PD）患者的抑郁与残疾之间的关系进行了研究。13%的患者目前患有重度抑郁症（MD），10%患有心境恶劣，32%有MD终生病史。抑郁与疾病严重程度和功能损害均显著相关。早发性PD（55岁之前）男性患者比晚发性男性患者有更多的情绪和焦虑障碍。右侧PD患者的抑郁症状明显多于左侧PD患者。多元回归分析显示，抑郁预示着男性（而非女性）的社交、角色和身体功能受损，且独立于疾病严重程度的影响。结果表明，治疗抑郁可能会改善功能；然而，性别差异的研究结果需要重复验证。
