Duffy J D, Kant R
Department of Psychiatry, Medical College of Pennsylvania, Pittsburgh, PA 15212, USA.
J Neuropsychiatry Clin Neurosci. 1996 Winter;8(1):92-6. doi: 10.1176/jnp.8.1.92.
Patients who develop psychosis or agitated behavior secondary to neurological disorders present a therapeutic dilemma. The authors review clinical efficacy and side effect profiles of clozapine in a cohort of 16 patients with various neurobehavioral disorders. One-third showed a marked decrease in symptoms while on clozapine. However, one-quarter developed an acute confusional state; of these, all had diffuse slowing on their baseline EEG prior to starting the drug.
因神经疾病继发出现精神病或激越行为的患者面临治疗困境。作者回顾了氯氮平在16例患有各种神经行为障碍患者中的临床疗效和副作用情况。三分之一的患者在服用氯氮平期间症状显著减轻。然而，四分之一的患者出现了急性意识模糊状态；在这些患者中，所有人在开始用药前基线脑电图均有弥漫性减慢。
