Suzuki S, Tanaka M, Masuko T, Hashimoto Y
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Biol Pharm Bull. 1995 Sep;18(9):1279-82. doi: 10.1248/bpb.18.1279.
Monoclonal antibodies targeting c-erbB-2 protooncogene product p185 were conjugated with adriamycin via a pH-sensitive spacer. The resultant antibody-adriamycin conjugates showed immunoselective binding, internalization and cytotoxicity to p185-positive human breast cancer cell SKBr-3 and gastric cancer cell MKN-7, but not to normal human lymphocytes.
靶向c-erbB-2原癌基因产物p185的单克隆抗体通过一个pH敏感间隔物与阿霉素偶联。所得的抗体-阿霉素偶联物对p185阳性的人乳腺癌细胞SKBr-3和胃癌细胞MKN-7表现出免疫选择性结合、内化及细胞毒性，但对正常人淋巴细胞无此作用。
