Peringa J, Fung K M, Muragaki Y, Trojanowski J Q
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA.
Curr Opin Neurol. 1995 Dec;8(6):437-40. doi: 10.1097/00019052-199512000-00006.
Medulloblastomas are prototypical of primitive neuroectodermal tumors which are some of the most frequent malignant brain tumors of childhood. The cell biology of medulloblastomas is still poorly understood, but recent studies of the expression of trophic factors and their receptors in medulloblastomas and the development of animal models of primitive neuroectodermal tumors may provide clues as to the induction or progression of these tumors. For example, they could clarify mechanisms that regulate cell death, proliferation and differentiation in these tumors.
髓母细胞瘤是原始神经外胚层肿瘤的典型代表，这类肿瘤是儿童时期最常见的恶性脑肿瘤之一。髓母细胞瘤的细胞生物学仍未被充分了解，但最近关于髓母细胞瘤中营养因子及其受体表达的研究以及原始神经外胚层肿瘤动物模型的开发，可能为这些肿瘤的诱发或进展提供线索。例如，它们可以阐明调节这些肿瘤中细胞死亡、增殖和分化的机制。
