Huston L J, Golko D S, Paton D M
Can J Physiol Pharmacol. 1977 Jun;55(3):609-14. doi: 10.1139/y77-084.
The effect of neuronal-uptake inhibitors on the guanethidine-induced inhibition of responses of rabbit vas deferens to transmural stimulation was investigated. The twitch and sustained responses were inhibited by about 70% by 1.2 X 10(-5) M guanethidine. Prior or subsequent exposure to the noradrenaline-uptake inhibitors, 3.3 X 10(-5) M cocaine, 10(-5)M nisoxetine, and 10(-7)M desipramine prevented or reversed these effects of guanethidine. The depressant effects of guanethidine were not modified by the serotonin-uptake inhibitor, 10(-6)M fluoxetine. The uptake of 5 X 10(-8)M (-)-[3H]noradrenaline by rabbit vas deferens was significantly reduced by guanethidine, cocaine, nisoxetine, and desipramine, but not by fluoxetine. It was concluded that guanethidine inhibited both the twitch and sustained responses of the vas by producing adrenergic-neuron blockade and that these effects were dependent on continued transport into adrenergic neurons.
研究了神经元摄取抑制剂对胍乙啶诱导的兔输精管对跨壁刺激反应抑制的影响。1.2×10⁻⁵ M胍乙啶可使抽搐反应和持续反应受到约70%的抑制。预先或随后暴露于去甲肾上腺素摄取抑制剂、3.3×10⁻⁵ M可卡因、10⁻⁵ M尼索西汀和10⁻⁷ M地昔帕明可预防或逆转胍乙啶的这些作用。5-羟色胺摄取抑制剂10⁻⁶ M氟西汀并未改变胍乙啶的抑制作用。胍乙啶、可卡因、尼索西汀和地昔帕明可显著降低兔输精管对5×10⁻⁸ M（-）-[³H]去甲肾上腺素的摄取，但氟西汀无此作用。得出的结论是，胍乙啶通过产生肾上腺素能神经元阻滞来抑制输精管的抽搐反应和持续反应，且这些作用依赖于其持续转运至肾上腺素能神经元。
